New Novartis Patents II
wytze (geno@zap.a2000.nl)
Fri, 17 Dec 1999 19:25:13 +0100
> The "invention" by Novartis apllies to transgenic plants with
> insecticdal properties.
> Toxins expressed by such transgenic plants include for example:
> Bacillus cereus proteins, Bacillus popliae proteins, Bacillus
> thuringiensis endotoxins Cry1A(a), Cry1A(b), Cry1A(c), CryIIA, IIIA,
> IIIB2, Cyt A, VIP1, VIP2, VIP3 or insecticidal proteins of bacteria
> colonising nematodes like Photorhabdus spp or Xenorhabdus spp. such as
> Photorhabdus luminescens, Xenorhabdus nematophilus etc.
> Proteinase inhibitors such as trypsin inhibitors, serine protease
> inhibitors, patatin, cystatin, papain inhibitors,
> Ribosome inactivating proteins(RIP) such as ricin maize RIP, abrin,
> luffin, saporin or bryodin.
> Plant lectins such as pealectin, barley lectin or Snowdrop lectin or
> agglutinins.
> Animal toxins such as scorpion toxins, spider vernons, wasp vernons and
> other insect specific neurotoxins;
> Steroid metabolism enzymes such as 3-hydroxysteroid oxidase,
> ecdysteroid-UDP-glycosyl transferase, cholesterol oxidases, ecdysone
> inhibitors, HMG-COA reductase, ionchannelblockers such as sodium and
> calcium, juvenile hormone esterase, diuretic hormone receptors, stilbene
> synthase, bibenzyl synthase, chitinase and glucanases.
>
> See also the following patents: EP374753, WO9307278, WO9534656,
> EP427529, EP451878
>
> The "invention" can be used on:
> Soy, maize, sorghum, cereals, potatoes, tomatoes, cotton but also on:
> fruits: stonefruit, pomefruit, apples, pears, plums, peaches, almonds,
> cherries, strawberries, raspberries, blackberries.
> Beans, lentils, peas, Oil crops such as rape, mustard, poppies, olives,
> sunflowers, coconuts, castor-oilplants, cacao, peanuts.
> Pumpkin, cucumber, melons.
> Fibre crops like cotton, hemp, flax, jute.
> Citrusfruits like lemon, orange, grapefruit, tangerine
> Vegetables like spinach, lettuce, carrots, asparagus, cabbage, carrots,
> onions, tomatoes, beet and capsicum.
> And also on avocado, cinnamonium, camphor, tobacco, nuts, coffee,
> eggplants, sugarcane, tea, pepper, grapevines, hops, the banana family,
> cereals.
>
> The reduction rate is 40-50% at least which can be increased by adding
> other compounds (see previous message).
>
> The application gives a whole list of biological examples, which I did
> not yet go through.
> The whole application is about 110 pages. It also lists the different
> nematodes and insects it works upon but also tables with a lot of other
> targets, like fungi, viruses etc.
> To me the "invention" is 0,1-99% proof that transgenic Bt plants are not
> so effective and have caused resistance already, in particular 95-99%.
> wytze
>
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