RE: 2,4-Dinitrophenol

Wilson, Dale (WILSONDO@phibred.com)
Wed, 4 Aug 1999 06:38:21 -0500

Klaus,

> may i conclude from the data above, that 2,4-d is used on one
> fourth of the total american wheat area and is NOT registered ??
> the chem-usage-file dates from may 99...

The common herbicide known as 2,4-D is 2,4-dichlorophenoxy acetic acid.
2,4-dinitrophenol is an entirely different thing. Dinitrophenol and its
derivatives such as Dinoseb are acutely toxic to many organisms because they
partition into the mitochondrial inner membrane and allow protons to leak
across the membrane, inhibiting capture of energy as ATP. A long time ago,
people put dinitrophenol in weight-loss pills, because the chemical causes
animals to burn calories like crazy (they get hot). But this proved to be
too dangerous.

See
http://ntp-server.niehs.nih.gov/cgi/iH_Indexes/Chem_H&S/iH_Chem_H&S_Frames.h
tml

2,4-D (that is 2,4 dichlorophenoxy acetic acid), derivatives, and related
compounds (synthetic auxins) are much less toxic to animals than
dinitrophenol (although they too can uncouple ATP production in high doses).
These herbicides are toxic to plants because they mimic the plant hormone
IAA (indole acetic acid) triggering destructive mis-cues in tissue growth in
the plant.

Dale

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